Marie Wikstrom Lindholm

Company: Silence Therapeutics

Job title: Chief Scientific Officer

Seminars:

Alternatives for Reducing Number of Undefined Stereo Centres in GalNAcConjugated siRNA 2:00 pm

• Regular phosphorothioate internucleotide linkages creates undefined stereo centers during solid phase synthesis • Phosphorodithioate internucleotide linkages circumvent undefined isomer formation while retaining or increasing metabolic stability • Synthetic RNA building blocks in key positions can reduce exonuclease mediated degradation without the need for thiolationRead more

day: Conference Day One