Alternatives for Reducing Number of Undefined Stereo Centres in GalNAcConjugated siRNA
Time: 2:00 pm
day: Conference Day One
Details:
• Regular phosphorothioate internucleotide linkages creates undefined stereo centers during solid phase synthesis
• Phosphorodithioate internucleotide linkages circumvent undefined isomer formation while retaining or increasing metabolic stability
• Synthetic RNA building blocks in key positions can reduce exonuclease mediated degradation without the need for thiolation
