Unprecedented, Tissue- & Modality-Agnostic Potency & Durability Improvement by Targeted Endosomal Escape In Vitro & In Vivo: an Update on Sapreme’s Unique Endosomal Escape Enhancer Platform
Time: 12:00 pm
day: Conference Day Two
Details:
• Efficient intracellular delivery of oligonucleotides remains a bottleneck in hepatic and especially extrahepatic tissues
• Sapreme’s endosomal escape enhancers allow for highly efficient and tissue specific intracellular delivery, using existing targeting ligands and payloads
• We will share data demonstrating in vivo liver, muscle and solid tumor delivery of oligonucleotides, allowing strong dose reductions whilst maintaining durability of effect
