Yacoub Habib
Chief Executive Officer Ophidion Inc
Yacoub Habib is the CEO and a driving force behind Ophidion Inc., a pioneering biopharmaceutical company focused on revolutionizing the treatment of central nervous system disorders. With over three decades of executive experience in business development at leading firms like Pfizer and Bristol-Myers Squibb, he possesses a proven track record of strategic leadership. At Ophidion, Yacoub is advancing a proprietary “Trojan horse” platform technology designed to non-invasively shuttle therapeutic agents across the blood-brain barrier. His work is pivotal in developing a promising pipeline of RNAi therapeutics aimed at halting neurodegenerative diseases like Huntington’s, Parkinson’s, and Alzheimer’s.
Seminars
Wednesday 28th January 2026
Overcoming the Blood-Brain Barrier Challenge on the Trojan Horse
3:00 pm
- Utilizing the advanced Trojan Horse formulations to enhance blood-brain barrier penetration, enabling systemic delivery of RNAi therapeutics for neurodegenerative diseases with gain in function
- Engineering receptor-mediated transcytosis to selectively transport siRNA and ASOs into the CNS, reducing off-target effects and improving therapeutic precision
- Demonstrating preclinical efficacy with a primary focus on Huntington’s disease, achieving significant knockdown of huntingtin protein and paving a clear path toward clinical development for severe neurological disorders
