Shanthi Ganesh

Company: Novo Nordisk

Job title: Director - Discovery Research

Seminars:

Targeting Tumor-Associated Immune Cells with RNAi-Lipid Conjugates 9:00 am

Refractory malignant solid tumors create an immunosuppressive TME which renders them resistant to standard-of-care immune checkpoint inhibitors How RNAi agents can silence CD274 (PD-L1) in tumor-associated immune cells, which mediate immune suppression in the TME Silencing Cd274 in antigen presenting cells remodeled the TME, increased cytotoxic T-cell infiltration and mediated single agent activity in immunotherapy…Read more

day: Conference Day One