Nicole Lykens
Co Founder & Chief Technology Officer Valaya Bio
Seminars
Thursday 28th January 2027
Roundtable: Understanding the Importance of Cell-Specific Delivery When Targeting the CNS Addressing cellular complexity within the CNS
3:00 pm
- Addressing whether investment/funding enthusiasm surrounding cell-type specific delivery is running ahead of the biology and where it is justified
- Considering whether to keep optimizing transferrin receptor shuttles which are heavily clinically validated or make the riskier bet on novel ligands to tune delivery
- Locating where the biggest opportunity for the delivery community to make progress in cell-type specific delivery is (RMT, nanoparticles, RNAi chemistry), and the gaps that need to be filled to get there faster
Friday 29th January 2027
Panel Discussion: Balancing Potency, Specificity & Therapeutic Index to Ensure Safe RNAi Therapies
1:30 pm
- Understanding the drivers of RNAi-related toxicity
- Optimizing delivery, chemistry & dosing to improve therapeutic index
- Building confidence in safety as RNAi expands beyond the liver
