Hanhua Huang

Company: Avidity Biosciences

Job title: VP Biology

Seminars:

Engineering Antibody Oligonucleotide Conjugates (AOCs): Preclinical, Clinical Progress and Lessons Learned 2:15 pm

Discussing antibody oligonucleotide conjugates and exploring how AOCs can help solve oligo delivery challenges Developing cellular and animal models with relevant disease readouts to demonstrate target engagement; AOC development candidate selection and clinical progressRead more

day: Conference Day Two

Streamlining Translation & De-risking RNAi Therapeutic Development with Optimal Selection of Preclinical Models & Appropriate Assays to Ensure Tolerable, Potent Therapies 12:01 pm

There are many promising RNAi therapeutic candidates at both the preclinical and clinical phase of development, but few drugs have yet been approved. To maximize clinical success, the right preclinical models should be used, mimicking the genotype of human patients. Assays to determine toxicity and efficacy must be precise, and dosing should be considered. Therefore,…Read more

day: Pre-Conference Workshop Day