Targeted Extra-Hepatic Delivery of Custom Oligonucleotide-Peptide Conjugates for Enhanced Tumor Bioavailability, Efficacy, & Safety in a Breast Cancer Model
Time: 4:45 pm
day: Conference Day Two
Details:
- How to design antisense oligonucleotide shortmers with custom RNA amidites for optimal efficacy and reduced off-target effects
- How to enhance tumor uptake and minimize liver accumulation of oligonucleotides via peptide ligand conjugation
- How to design tissue-specific peptide ligands for RNAi therapeutics using AI/ML-driven approach
UNPUBLISHED DATA
