Seizing the Value of RNAi Therapeutics for Oncology to Develop Precise, Effective Treatments for Patients
Time: 2:00 pm
day: Pre-Conference Workshop Day
Details:
RNAi therapeutics holds promise for treating complex genetic diseases such as cancer by targeting multiple oncogenes, but release of the therapeutic payload must be rapid and precise, and the heterogeneity of tumors must be considered. Therefore, this Workshop will address:
- How to identify genetic targets in heterogenous tumors to increase correlation in response at the preclinical and clinical stage
- How to design miRNA to target multiple oncogenes to overcome tumor resistance and limit toxicity
- How to integrate chemotherapeutic nucleoside analogs into miRNA to amplify tumor killing and induce a durable anti-cancer response
- How to stimulate release of siRNA from the endosome to invoke a rapid response against tumor cells
