Maximizing Bioavailability of RNAi Therapies with Oligonucleotide Conjugates to Reach Previously Undruggable Therapeutic Targets
Time: 10:00 am
day: Pre-Conference Workshop Day
Details:
Whilst the hunt for next-generation delivery platforms continues, and the scope for targeting extra-hepatic tissue increases, the success of RNAi therapeutics is limited if bioavailability is not addressed. For RNAi therapies to successfully induce gene silencing, the payload must be released effectively to the target tissue. As such, this workshop will address:
- Utilizing machine learning and algorithms to identify targets and design precise siRNA sequences
- How siRNA conjugates can improve targeted delivery and bioavailability in extrahepatic tissue
- How to select optimized delivery systems which amplify bioavailability whilst maintaining target specificity
