Leveraging the STRIKE™ Platform for Targeted and Specific Gene Silencing Kidneys for Systemic Diseases
- Understanding how the STRIKE™ platform utilizes proprietary ligand-siRNA conjugates (STRIKERs) for precise, receptor-mediated uptake in target kidney cells, minimizing systemic exposure and off-site toxicity.
- Exploring how megalin-STRIKERs are engineered to enhance cellular internalization into proximal tubule cells, improving the efficiency of gene silencing
- Evaluating how this targeted delivery approach enables potent and durable silencing, providing a long-term therapeutic strategy