DELiveri®: discovering cell specific delivery molecules for RNAi using high throughput screens with millions of conjugates
- Exploring the role of DELiveri® as a powerful product engine to enable functional screens of millions of delivery molecules in human cells in a one-pot reaction, for improved specificity of RNAi therapies
- Evaluating the quantitative output of the screen, providing a score for each molecule, and setting the basis to train AI algorithms
- Sharing insights from over 30 screens conducted across multiple primary human cell types, along with in-vivo validation data for novel compounds, to establish a robust predictive framework for translating in vitro results into effective in vivo therapies