Amide-Modified RNA: Using Protein Backbone to Improve Specificity of siRNAs

Time: 2:30 pm
day: Conference Day One

Details:

  • Amides are excellent mimics of phosphate linkages in RNA and are well tolerated in the guide strand of siRNAs
  • Amide modification at the 5’-end (position 1) of the passenger strand suppresses its undesired off-target activity
  • Amide modification in the seed region of the guide strand suppresses undesired microRNA-like off-target activity

UNPUBLISHED DATA

Speakers:

Eriks Rozners
Eriks Rozners