Marie Wikström Lindholm

Company: Silence Therapeutics
Job title: SVP & Head of Molecular Design
Seminars:
Unexpected Benefits of Replacing Phosphorothioates with Achiral Phosphordithioates for siRNA End Stabilization 1:30 pm
Phosphordithioates (PS2s) were investigated as they could simplify oligonucleotide purification by replacing the undefined stereo centres introduced in phosphorothioate (PS) couplings A single PS2 provides a similar strand stability as two PS In vivo, PS2 linkages appears to introduce a longer duration of action than PS-containing siRNA with the same sequenceRead more
day: Track A Day 1 AM