Marie Wikström Lindholm

Marie Wikström Lindholm

Company: Silence Therapeutics

Job title: SVP & Head of Molecular Design


Unexpected Benefits of Replacing Phosphorothioates with Achiral Phosphordithioates for siRNA End Stabilization 1:30 pm

Phosphordithioates (PS2s) were investigated as they could simplify oligonucleotide purification by replacing the undefined stereo centres introduced in phosphorothioate (PS) couplings A single PS2 provides a similar strand stability as two PS In vivo, PS2 linkages appears to introduce a longer duration of action than PS-containing siRNA with the same sequenceRead more

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