Justin Murray

Justin Murray

Company: Amgen

Job title: Director Research


Discovery of a Minor Allele-Specific siRNA for PNPLA3 I148M to Treat NASH 11:00 am

Human genome wide association studies confirm the association of the rs738409 single nucleotide polymorphism (SNP) in the gene encoding protein patatin like phospholipase domain containing 3 (PNPLA3) with nonalcoholic fatty liver disease (NAFLD); the presence of the resulting mutant PNPLA3 I148M protein is a driver of nonalcoholic steatohepatitis (NASH) While Pnpla3-deficient mice do not display…Read more

day: Day Two

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