Job title: Co-Founder & Chief Scientific Officer
Dr. Sharp is is Professor of Physiology and Biophysics, Ophthalmology and Visual Sciences, and Neuroscience at the Albert Einstein College of Medicine in New York City. He is recognized as one of the world’s foremost experts on microtubules and cell movement, with numerous publications in prestigious journals including Cell, Nature, Nature Cell Biology, and Proceeding of the National Academy of Sciences.
His career-long research focus has been on the roles and regulation of the microtubule cytoskeleton in cell migration, division, and morphogenesis, as well as harnessing these mechanisms for tissue repair. He has co-authored over 60 papers on this topic to date and has received multiple research grants from federal and state government agencies and private foundations. Dr. Sharp’s research has led to the identification of enzymes that can be targeted in vivo to predictably alter cellular motility in a variety of clinical contexts related to tissue repair and regeneration, for which he has been issued seven U.S. patents. He is now leading the therapeutic translation of these findings for MicroCures.
Dr. Sharp has been the recipient of numerous research awards from the National Institutes of Health and the Department of Defense. He also has received the LaDonne H. Schulman Excellence in Teaching Award and is a scholar of the Leukemia and Lymphoma Society. Dr. Sharp holds a bachelor’s degree in psychology and a Ph.D. in neuroscience at the University of Wisconsin.
Harnessing Cell Migration to Repair Tissue Using RNAi-Enabled Therapeutics 4:10 pm
• We have identified several previously unknown or uncharacterized microtubule regulatory proteins that, when knocked-down using siRNA, demonstrate dramatic therapeutic benefits – especially in tissue repair after trauma • MicroCures has completed extensive animal studies on its drug candidate, siFi2, and plans to begin first-in-human clinical trials in late 2020Read more