Job title: Director
Brooke Rock is a Director in the Pharmacokinetics and Drug Metabolism at Amgen Inc. Brooke received her PhD degree from University of Washington, School of Pharmacy in medicinal chemistry. Her research has focused on in vitro-in vivo drug metabolism, enzymology, in silico kinetic modeling, clinical DDI predictions and pharmacokinetics.
Transforming Traditional SM ADME Assays to Support the Translation of siRNA Pharmacology from the Benchtop to the Clinic 3:30 pm
The physicochemical properties of siRNA push this new modality outside of the small molecule classification However, there exist opportunities to apply learnings from small molecules to underwrite the PK-PD relationships, inform structural integrity, and understand biodistribution This presentation will discuss the above three topics along with the strategy to effectively characterize siRNA from early discovery…Read more