Transforming Traditional SM ADME Assays to Support the Translation of siRNA Pharmacology from the Benchtop to the Clinic

Time: 3:30 pm

Details:

  • The physicochemical properties of siRNA push this new modality outside of the small molecule classification
  • However, there exist opportunities to apply learnings from small molecules to underwrite the PK-PD relationships, inform structural integrity, and understand biodistribution
  • This presentation will discuss the above three topics along with the strategy to
    effectively characterize siRNA from early discovery into the clinical setting

Speakers: