Round Table: Tackling Toxicology Studies in Animal Models

Time: 12:30 pm
day: Day Two


  • How to show knockdown in rodent species?
  • What are the best models for determining safety and efficacy?
  • Optimizing the dosing strategy to reduce toxicity while achieving a therapeutic effect
  • How can adding a targeting ligand benefit improve efficacy?
  • What chemical modifications can be made to reduce toxicity?
  • How to tackle IND-enabling studies in preclinical pharmacology and toxicology models
  • What tools are available to successfully assess PKPD?
  • What PKPD properties are optimal for the desired effect?