MCJ siRNA: A Novel Metabolic Regulator for Treating Acute & Chronic Liver Diseases

Time: 4:30 pm
day: Track B Day 1 PM


  • Identified MCJ/DNAJC15, a novel negative regulator of mitochondrial metabolism, which is highly expressed in liver, kidney and heart
  • Knockdown is effective in treating acute and chronic liver diseases, including acute drug-induced injury, NAFLD/NASH, cholestatic liver disease and liver fibrosis
  • Designed novel siRNA drug candidates and appropriate delivery technologies to target liver, and also kidney and heart as additional disease indications