Efficient On-Target Delivery of Oligonucleotides to the Liver & Beyond: in vitro & in vivo Performance of Sapreme’s Endosomal Escape Enhancers

Time: 9:00 am
day: Day Two


  • Endosomal escape remains a bottleneck for efficient oligo therapeutics delivery
  • Sapreme has developed a series of endosomal escape enhancing compounds, derived from a natural product evolved to mediate endosomal escape
  • Optimized for conjugation to targeting ligand and payload through industry standard chemistries, the Sapreme compounds lend themselves to facile incorporation into existing compounds and proven manufacturing methods